BP501T MEDICINAL CHEMISTRY – II (Theory) Notes

5.1 Antidiabetic agents Insulin and its preparations Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride. Biguanides: Metformin. Thiazolidinediones: Pioglitazone, Rosiglitazone. Meglitinides: Repaglinide, Nateglinide. Glucosidase inhibitors: Acrabose, Voglibose. Please follow the link  Antidiabetic agents

Local Anesthetics: SAR of Local anesthetics Benzoic Acid derivatives ; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine,Piperocaine. Amino Benzoic acid derivatives : Benzocaine*, Butamben, Procaine*, Butacaine,Propoxycaine, Tetracaine, Benoxinate. Lidocaine/Anilide derivatives : Lignocaine, Mepivacaine, Prilocaine, Etidocaine. Miscellaneous : Phenacaine, Diperodon, Dibucaine.* Please follow the link  Local Anesthetics  

4.6 Thyroid and antithyroid drugs L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole. Please follow the link Presentation:  Thyroid Hormones                                    Youtube Video:  Thyroid Animation                                     Youtube Video:  Thyroid Hormone Synthesis and Antithyroid drugs

  4.2 Sex hormones : Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol,Oestrione, Diethyl stilbestrol. Please follow the link   Sex hormones 4.3 Drugs for erectile dysfunction: Sildenafil, Tadalafil Please follow the link  Drugs for erectile dysfunction 4.4 Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol Please follow the link  Oral contraceptives

 4.5 Corticosteroids Cortisone, Hydrocortisone, Prednisolone, Betamethasone,Dexamethasone Please follow the link  Adrenocorticoids or Corticoids

4.1 Drugs acting on Endocrine system Nomenclature, Stereochemistry and metabolism of steroids Please follow the links Steroid Nomenclature and stereochemistry Wilson and Gisvold’s Textbook Introduction of steroids  Steroid Assignment follow the link to complete the assignment Steroid Assignment-5   with answer supplement

3.2  Anti-hyperlipidemic agents : Clofibrate, Lovastatin, Cholestyramine and Colestipol Please follow the link  Anti-hyperlipidemic agents, Coagulant & Anticoagulants 3.3 Coagulant & Anticoagulants : Menadione, Acetomenadione, Warfarin*,Anisindione, clopidogrel Please follow the link  Coagulant & Anticoagulants 3.4 Drugs  used in Congestive  Heart  Failure: D igoxin Digitoxin, Nesiritide, Bosentan, Tezosentan. Please follow the link  Drugs  used in Congestive  Heart  Failure 

3.1  Anti-arrhythmic Drugs : Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol. Please follow the link  Antiarrhythmic Agents

Anti-hypertensive Agents : Timolol, Captopril, Lisinopril, Enalapril, Benazeprilhydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride. Please follow the link   Anti-hypertensive Agents

Anti-anginal : Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbidedinitrite*, Dipyridamole. Follow the link    Antianginal Agents   Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazemhydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.  Follow the link   Calcium channel blockers Diuretics: Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide. Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol Please follow the link  Diuretics  

  Alkylatingagents:  Meclorethamine* Cyclophosphamide,   Melphalan, Chlorambucil, Busulfan, Thiotepa Antimetabolites: Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine,Cytarabine, Methotrexate*, Azathioprine Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate Miscellaneous: Cisplatin, Mitotane Please follow the link  Anticancer Agents

Antihistaminic agents: Histamine, receptors and their distribution in the human body H 1 –antagonists: Diphenhydramine hydrochloride*, Dimenhydrinate,Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium H 2 -antagonists: Cimetidine*, Famotidine, Ranitidin. Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole Please follow the Link   Antihistaminics

  BP501T           MEDICINAL CHEMISTRY – II (Theory)                                        3 L + 1T / Week Scope:  This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure-activity relationships of drugs, the importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on the chemical synthesis of important drugs under each class. Objectives: Upon completion of the course the the student shall be able to 1.       Understand the chemistry of drugs with respect to their pharmacological activity 2.       Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs 3.       Know the Structural Activity Relationship of different class of drugs 4.       Study the chemical synthesis of selected drugs   Sr. No. Content: Study of the development of the following classes of drugs, Classification, mechan